KMID : 0624620090420090605
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BMB Reports 2009 Volume.42 No. 9 p.605 ~ p.610
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Enhanced functional and structural properties of high-density lipoproteins from runners and wrestlers compared to throwers and lifters
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Lee Hwa-Hyung
Park Jeong-Euy Choi In-Ho Cho Kyung-Hyun
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Abstract
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Plasma high-density lipoprotein cholesterol (HDL-C) levels are inversely correlated with the risk of cardiovascular disease, and are known to increase with repetitive exercise. In the current study, HDL fractions from athletes¡¯ sera were isolated and compared as a function of the type of sport (runners [n = 10], throwers [n = 10], wrestlers [n = 10], and weight lifters [n = 8]), and as an age- and gender-matched reference group (n = 14). Among athletes, HDL from runners had the strongest antioxidant activity. Immunodetection showed that runners and wrestlers had the highest levels of apoA-I and lowest levels of apoA-II in their HDL. Electron microscopy also revealed that HDL2 of runners and wrestlers were the largest in size. In conclusion, although all athlete groups had significantly better serum lipid/lipoprotein profiles than the reference group, runners and wrestlers had the most desirable lipoprotein function and structure, including antioxidant activity, HDL-associated enzyme activities and increased particle size.
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KEYWORD
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Antioxidant, Apolipoproteins, Cholesteryl ester transfer protein, High-density lipoproteins
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